| Bill & Melinda Gates Foundation | 17 | $20.5m |
| John D and Catherine T MacArthur Foundation | 2 | $6.2m |
| Houston Endowment | 4 | $5.0m |
| Arnold Ventures (Laura and John Arnold Foundation) | 6 | $3.8m |
| Gordon and Betty Moore Foundation | 11 | $2.7m |
| ROBERT J & HELEN C KLEBERG FOUNDATION | 2 | $2.1m |
| HUFFINGTON FOUNDATION | 2 | $2.0m |
| SCHWAB CHARITABLE FUND | 2 | $1.8m |
| David and Lucile Packard Foundation | 8 | $1.8m |
| William and Flora Hewlett Foundation | 4 | $1.7m |
| ROCKEFELLER PHILANTHROPY ADVISORS INC | 1 | $1.6m |
| Donors Trust Inc | 3 | $1.2m |
| GREATER HOUSTON COMMUNITY FOUNDATION | 2 | $1.2m |
| DAN L DUNCAN FOUNDATION | 2 | $999.7k |
| VANGUARD CHARITABLE ENDOWMENT PROGRAM | 2 | $913.4k |
| THE KAVLI FOUNDATION | 2 | $687.5k |
| Simons Foundation | 6 | $627.9k |
| NATIONAL PHILANTHROPIC TRUST | 2 | $514.9k |
| AMERICAN ENDOWMENT FOUNDATION | 3 | $508.2k |
| THE BESSEMER GIVING FUND C/O BESSEMER TRUST COMPANY TRUSTEE | 2 | $410.0k |
| Kauffman Foundation | 6 | $367.9k |
| Silicon Valley Community Foundation | 2 | $344.0k |
| THE LEMELSON FOUNDATION | 2 | $300.0k |
| The Brown Foundation Inc | 19 | $288.0k |
| THE DALLAS FOUNDATION | 1 | $229.3k |
| J. Paul Getty Trust | 1 | $216.0k |
| THE ERIC AND WENDY SCHMIDT FUND FOR STRATEGIC INNOVATION | 1 | $173.8k |
| Breakthrough T1D Canada/Percée DT1 Canada | 1 | $169.1k |
| Annie E. Casey Foundation | 3 | $160.4k |
| GS DONOR ADVISED PHILANTHROPY FUND FOR WEALTH MANAGEMENT INC | 1 | $154.0k |
| Wallace Foundation | 3 | $150.0k |
| The Robert and Janice McNair Foundation | 1 | $133.5k |
| WILLIAM T GRANT FOUNDATION INC | 1 | $102.3k |
| CHARITIES AID FOUNDATION AMERICA | 3 | $91.6k |
| THE SAN DIEGO FOUNDATION | 1 | $80.0k |
| The Cynthia & George Mitchell Foundation | 4 | $64.8k |
| BATON ROUGE AREA FOUNDATION | 2 | $64.5k |
| American Heart Association Inc | 1 | $64.1k |
| Howard Hughes Medical Institute | 2 | $60.0k |
| THE GREENWALL FOUNDATION | 1 | $50.0k |
| COMMUNITIES FOUNDATION OF TEXAS INC | 2 | $45.0k |
| AUSTIN COMMUNITY FOUNDATION INC | 2 | $41.0k |
| COLUMBUS FOUNDATION | 1 | $40.0k |
| The Winston-Salem Foundation | 2 | $40.0k |
| AMERICAN GIFT FUND | 2 | $40.0k |
| Tulsa Community Foundation | 3 | $36.2k |
| NATL CHRISTIAN CHARITABLE FDN INC | 2 | $27.8k |
| SAINT PAUL & MINNESOTA FOUNDATION | 1 | $25.0k |
| ALBERT & ETHEL HERZSTEIN CHARITABLE FOUNDATION | 1 | $25.0k |
| THE US CHARITABLE GIFT TRUST | 1 | $20.3k |